CM037
Based on 1 publication(s) in Google Scholar
CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics.
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- Pureté: 99.55%
- CAS No.: 896795-60-1
- Formule: C21H25N3O3S2
- Masse moléculaire:431.57
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) CM037
More
Activité biologique
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ALDH1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OV-90 | EC50 |
3.96 μM
Compound: 2
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Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
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[PMID: 29767973] |
Cell viability and VEGF release experiments: CM037 (10 μM; 18 h) dose-dependently downregulates the expression and secretion of VEGF in MCF-7 cells and inhibited the proliferation and migration of endothelial cells[2].
Western blot experiment: CM037 (1 μM, 10 μM; 18 h) significantly reduces the levels of HIF-1α and VEGF proteins and blocked the RA/RAR signaling pathway[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 breast cancer cells
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Concentration:1-10 μM
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Incubation Time:18-48 h
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Result:Dose-dependently reduced VEGF secretion (ELISA) and HIF-1α expression (WB) in MCF-7 cells, without significant cytotoxicity (MTT assay).
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Cell Line:MCF-7 cells
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Concentration:1 μM
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Incubation Time:48 h
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Result:Decreased phosphorylated RARα and HIF-1α protein levels, concurrent with reduced VEGF expression, indicating inhibition of RA/RAR-mediated angiogenic signaling.
Chemical Information
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CAS No. 896795-60-1
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Appearance Solid
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Masse moléculaire 431.57
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Formule C21H25N3O3S2
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Color Light brown to brown
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SMILES
O=C1C2=C(N=C(SCC(OCC)=O)N1CCCN3CCCC3)C4=CC=CC=C4S2
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Synonyms
A37
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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iScience
Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3. [Abstract]2025 Oct 3;28(11):113675. PMID: 41210994
Solvant et solubilité
DMSO : 83.33 mg/mL (193.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Morgan CA, et al. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J Med Chem. 2015 Feb 26;58(4):1964-75.[Content Brief] [Content Brief]
[2]. Ciccone V, et al. Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells. J Exp Clin Cancer Res. 2018 Dec 12;37(1):311. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3171 mL | 11.5856 mL | 23.1712 mL | 57.9280 mL |
| 5 mM | 0.4634 mL | 2.3171 mL | 4.6342 mL | 11.5856 mL | |
| 10 mM | 0.2317 mL | 1.1586 mL | 2.3171 mL | 5.7928 mL | |
| 15 mM | 0.1545 mL | 0.7724 mL | 1.5447 mL | 3.8619 mL | |
| 20 mM | 0.1159 mL | 0.5793 mL | 1.1586 mL | 2.8964 mL | |
| 25 mM | 0.0927 mL | 0.4634 mL | 0.9268 mL | 2.3171 mL | |
| 30 mM | 0.0772 mL | 0.3862 mL | 0.7724 mL | 1.9309 mL | |
| 40 mM | 0.0579 mL | 0.2896 mL | 0.5793 mL | 1.4482 mL | |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL | 1.1586 mL | |
| 60 mM | 0.0386 mL | 0.1931 mL | 0.3862 mL | 0.9655 mL | |
| 80 mM | 0.0290 mL | 0.1448 mL | 0.2896 mL | 0.7241 mL | |
| 100 mM | 0.0232 mL | 0.1159 mL | 0.2317 mL | 0.5793 mL |
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