CPN-219
Based on 1 Customer Validation
CPN-219, a next-generation hexapeptidic NMUR2 agonist, achieves a dose-dependent and selective activation of NMUR2 with an EC50 value of 2.2 nM.
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- Pureté: 99.08%
- CAS No.: 2240202-02-0
- Formule: C40H72N12O8
- Masse moléculaire:849.08
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Peptide Library
HY-L105
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Highly Selective Activators Library
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Bioactive Compound Library Max
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Peptide Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
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Activité biologique
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NMUR2 |
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
2.2 nM
Compound: 3a
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Agonist activity at human NMUR2 expressed in CHO cells by Fluo-4-AM dye based calcium mobilization assay
Agonist activity at human NMUR2 expressed in CHO cells by Fluo-4-AM dye based calcium mobilization assay
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[PMID: 32247748] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddY mice[1].
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Dosage:250, 100, 25 µg/mouse.
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Administration:Applied to the nasal cavity; at days 1 and 4
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Result:Suppressed body weight gain of mice in a dose-dependent manner.
Chemical Information
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CAS No. 2240202-02-0
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Appearance Solid
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Masse moléculaire 849.08
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Formule C40H72N12O8
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Color White to off-white
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Sequence
{3-Cyclohexylpropionyl}-Leu-Leu-{Dbu}-Pro-Arg-Asn-NH2
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Sequence Shortening
{3-Cyclohexylpropionyl}-LL-{Dbu}-PRN-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
H2O : 50 mg/mL (58.89 mM; Need ultrasonic)
DMSO : 50 mg/mL (58.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.1777 mL | 5.8887 mL | 11.7775 mL | 29.4436 mL |
| 5 mM | 0.2355 mL | 1.1777 mL | 2.3555 mL | 5.8887 mL | |
| 10 mM | 0.1178 mL | 0.5889 mL | 1.1777 mL | 2.9444 mL | |
| 15 mM | 0.0785 mL | 0.3926 mL | 0.7852 mL | 1.9629 mL | |
| 20 mM | 0.0589 mL | 0.2944 mL | 0.5889 mL | 1.4722 mL | |
| 25 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1777 mL | |
| 30 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9815 mL | |
| 40 mM | 0.0294 mL | 0.1472 mL | 0.2944 mL | 0.7361 mL | |
| 50 mM | 0.0236 mL | 0.1178 mL | 0.2355 mL | 0.5889 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CPN-219 Related Classifications
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