CV-6504
CV-6504 is a dual inhibitor of TXA2 synthase and 5-lipoxygenase. CV-6504 can scavenge ROS and exhibit antitumor activity. CV-6504 can be used for the researches of cancer, inflammation and cardiovascular disease.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 117574-40-0
- Formule: C15H15NO2
- Masse moléculaire:241.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
TXA2 synthase |
5-Lipoxygenase |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MAC13 | IC50 |
6.3 x 10-6M
Compound: CV-6504
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Inhibitory activity against MAC13 cell lines
Inhibitory activity against MAC13 cell lines
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[PMID: 12852938] |
| MAC16 | IC50 |
4.75 x 10-6M
Compound: CV-6504
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Inhibitory activity against MAC16 cell lines
Inhibitory activity against MAC16 cell lines
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[PMID: 12852938] |
| RBL-1 | IC50 |
1.8 x 10-6M
Compound: 24
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The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells
The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells
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[PMID: 1992126] |
| RBL-1 | IC50 |
62 nM
Compound: CV-6504
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The compound was tested for inhibitory activity against 5-HETE synthesis in rat RBL-1
The compound was tested for inhibitory activity against 5-HETE synthesis in rat RBL-1
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[PMID: 1635053] |
Chemical Information
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CAS No. 117574-40-0
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Masse moléculaire 241.29
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Formule C15H15NO2
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SMILES
O=C1C(C)=C(C)C(C(C)=C1CC2=CC=CN=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Terao S, et al. Synthesis and biological evaluation of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (CV-6504), a dual inhibitor of TXA2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species (AOS). Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:173-6. [Content Brief]
[2]. Hussey HJ, et al. Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). Br J Cancer. 1997;75(6):845-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CV-6504 Related Classifications
HY-19064 Related Classifications
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