Dehydrojuncusol
Dehydrojuncusol, a potent HCV inhibitor, targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A direct-acting antivirals. Dehydrojuncusol significantly inhibits HCV infection when added after virus inoculation of HCV genotype 2a (EC50=1.35?μM).
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- CAS No.: 117824-04-1
- Formule: C18H16O2
- Masse moléculaire:264.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
15.6 μM
Compound: Dehydrojuncusol
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Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
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[PMID: 29280630] |
Dehydrojuncusol (Huh-7 cells were infected with HCV in cell culture; 0-9.4 μM; 48 hours) inhibits HCV infection in a dose-dependent manner. Dehydrojuncusol inhibits HCV infection in Primary human hepatocytes (PHH)[1].
The EC50 of dehydrojuncusol is 1.35 μM when added continuously, 8.21 μM when added during inoculation, and 1.53 μM when added postinoculation, confirming the major effect of the molecule at the postinoculation step. The toxicity of the compound on Huh-7 cells is also tested in parallel at different time points (24 h, 48 h, and 72 h). The results shows that the CC50 of Dehydrojuncusol Is approximately 75.6 μM, which is much higher than the active dose, yielding a selective index of 56[1].
Dehydrojuncusol is able to inhibit RNA replication of two frequent daclatasvir-resistant mutants (L31M or Y93H in NS5A). Dehydrojuncusol inhibits HCV RNA replication[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 117824-04-1
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Masse moléculaire 264.32
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Formule C18H16O2
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SMILES
OC1=CC=C2C3=C(C=C)C(C)=C(O)C=C3C=CC2=C1C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydrojuncusol Related Classifications
HY-N8188 Related Classifications
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