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Cat. No.: HY-182395

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DM175

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454.

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CAS No.: 832119-34-3
Formule: C₂₅H₂₄N₂O₄
Masse moléculaire:416.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

DM175 Chemical Structure

CAS No.: 832119-34-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454^[1].

In Vitro

DM175 is a partial agonist of FXR LBD, which induces the outward movement of Trp454, a conformational change distinct from that induced by full FXR agonists^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 832119-34-3
Masse moléculaire 416.47
Formule C₂₅H₂₄N₂O₄
SMILES

O=C(C1=CC=C(NC(C2=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=CC=C2)=O)C=C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Miyata S, et al. Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists. Sci Rep. 2021;11(1):9196. Published 2021 Apr 28. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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