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Dostarlimab

(Synonyms: TSR-042; ANB-011; WBP-285)
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Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively.

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  • Pureté: 98.92%
  • CAS No.: 2022215-59-2
  • Masse moléculaire:144.18 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Dostarlimab
  • Experimental Validation Results for Dostarlimab
  • Experimental Validation Results for Dostarlimab
  • Dostarlimab Chemical Structure
    Dostarlimab Chemical Structure
CAS No.: 2022215-59-2
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Dostarlimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized PD-1 Protein, Human can bind Dostarlimab. The EC50 for this effect is 12.16 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 10 ng/mL PMA and 1 μg/mL Ionomycin co-stimulated Jurkat cells(24h) with Dostarlimab (HY-P99345, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Dostarlimab Chemical Structure
    1/16
  • Dostarlimab
  • Immobilized PD-1 Protein, Human can bind Dostarlimab. The EC50 for this effect is 12.16 ng/mL.
  • Flow cytometric analysis of 1X106 10 ng/mL PMA and 1 μg/mL Ionomycin co-stimulated Jurkat cells(24h) with Dostarlimab (HY-P99345, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).