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Cat. No.: HY-P2692A

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DT-2

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM).}}

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CAS No.: 1220985-78-3
Formule: C₁₂₂H₂₂₃N₅₃O₂₃
Masse moléculaire:2800.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

DT-2 Chemical Structure

CAS No.: 1220985-78-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM)^[1].}}

Chemical Information

CAS No. 1220985-78-3
Masse moléculaire 2800.42
Formule C₁₂₂H₂₂₃N₅₃O₂₃
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-NH2
Sequence Shortening

YGRKKRRQRRRPPLRKKKKKH-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nat Commun

Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice. [Abstract]

2024 Jul 18;15(1):6058. PMID: 39025877
J Ethnopharmacol

Yiqi Huoxue formula promotes post-myocardial infarction angiogenesis by modulating mitochondria-associated membranes (MAMs) and calcium homeostasis via the cGMP/PKG signaling pathway. [Abstract]

2026 Jun 4:370:121936. PMID: 42248375

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pinkse MWH, et al. Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem. 2009 Jun 12;284(24):16354-16368. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Publications (2)
Pureté et documentation
Références

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DT-2

Publications Citing Use of MedChemExpress (MCE) DT-2