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Cat. No.: HY-182255

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ED-594

ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes.

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CAS No.: 217187-87-6
Formule: C₃₃H₃₀N₄O₁₆
Masse moléculaire:738.61

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Please store the product under the recommended conditions in the Certificate of Analysis.

ED-594 Chemical Structure

CAS No.: 217187-87-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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Description

ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes^[1].

IC₅₀ & Target^[1]

Human Endogenous Metabolite

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In Vitro

ED-594 (15-30 min) is formed via glucuronidation of NB-506 in mouse, rat, and human liver microsomes with distinct apparent kinetic parameters, and no ED-594 formation occurs in dog liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 217187-87-6
Masse moléculaire 738.61
Formule C₃₃H₃₀N₄O₁₆
SMILES

O=C1C2=C3C(N([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C5=C(O)C=CC=C53)=C6C(C7=CC=CC(O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=C7N6)=C2C(N1NC=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Takenaga N, et al. In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans. Drug Metab Dispos. 1999 Feb;27(2):213-20. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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ED-594

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