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United States

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Cat. No.: HY-155676

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eIF4E-IN-5

eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation.

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Formule: C₃₀H₃₉Cl₂N₆O₈P
Masse moléculaire:713.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

eIF4E-IN-5 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation^[1].

Chemical Information

Masse moléculaire 713.55
Formule C₃₀H₃₉Cl₂N₆O₈P
SMILES

NC1=NC2=C(C(N1)=O)[N+](CC3=CC4=C(N3)C=CC(Cl)=C4)=CN2C/C=C\CP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O.[Cl-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cárdenas EL, et al. Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer. J Med Chem. 2023 Aug 10;66(15):10734-10745. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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