FG-3019
Based on 2 publication(s) in Google Scholar
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : ≥99.0%
- CAS No.: 946415-13-0
- Masse moléculaire:144.86 kDa
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Stockage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) FG-3019
More-
WB
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Histological Imaging/Staining
Activité biologique
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CTGF
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized CCN2/CTGF Protein, Human can bind Pamrevlumab . The EC50 for this effect is 6.731 ng/mL.
Chemical Information
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CAS No. 946415-13-0
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Appearance Liquid
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Masse moléculaire 144.86 kDa
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Color Colorless to light yellow
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SMILES
[FG-3019]
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Synonyms
Pamrevlumab; Anti-Human CTGF Recombinant Antibody
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models. [Abstract]2025 Sep 30;16(1):8710. PMID: 41027873 -
FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.
Wild-type (WT) mice were treated with PBS, and Mdx mice were treated with PBS, FG-3019 (50 mg/kg), TGF-β1 antibody (TGF-β1 ab), FG-3019 + TGF-β1 antibody (CTGF + F + T), and IgG for 6 weeks. Western blot analysis of myofibril and collagen III levels was then performed.
FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.
Masson staining was used to detect the diaphragm of wild-type (WT) mice treated with PBS, and mdx mice treated with PBS, Apc003OA, FG-3019 (50 mg/kg), Apc003OA+BP, and BP.
Pureté et documentation
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Fiche technique (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. [Content Brief]
[2]. Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)