FK 33-824

FK 33-824 (0.01-1 µM; 3 h) directly inhibits ACTH release from the anterior pituitary of female Wistar rats in vitro, where 1 µM inhibits basal ACTH secretion and 0.1 and 1 µM attenuate LVP-stimulated ACTH release^[1].
FK 33-824 (0.1 µM; 3 h) does not directly affect basal or dopamine-inhibited PRL release from the anterior pituitary of female Wistar rats in vitro^[1].
FK 33-824 increases the population spike response evoked in rat hippocampal CA1 slices, with an EC₅₀ of 13 nM^[2].
FK 33-824 (1 nM; up to 30 min) does not significantly affect phospholipase C-mediated inositol phosphate accumulation in porcine granulosa cells from large follicles^[4].
FK 33-824 (1 nM; 4 h) maintains the inhibition of E2 secretion in PKC-deficient porcine granulosa cells^[4].
FK 33-824 (1 nM; 4 h) inhibits E2 secretion in porcine granulosa cells, and PMA at 10 and 100 nM abolishes this inhibition^[4].
FK 33-824 (1 nM) completely eliminates hCG-stimulated progesterone secretion in porcine small luteal cells, but does not affect basal progesterone secretion in SLCs or LLCs^[7].
FK 33-824 (1 nM; 12 h) increases cAMP release in porcine large luteal cells and decreases cGMP release in porcine small luteal cells within 12 hours^[7].