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Ganitumab

(Synonyms: AMG 479; Human Anti-IGF1R Recombinant Antibody)
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Based on 1 publication(s) in Google Scholar

Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.

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  • Pureté: 96.00%
  • CAS No.: 905703-97-1
  • Masse moléculaire:145.743 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ganitumab
  • Experimental Validation Results for Ganitumab
  • Experimental Validation Results for Ganitumab
  • Ganitumab Chemical Structure
    Ganitumab Chemical Structure
CAS No.: 905703-97-1
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[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Ganitumab (HY-P99294, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.

  • 1/16

    Loaded Ganitumab on AHC2 biosensor, can bind IGF-I R Protein, Human (HEK293, His-Avi, HY-P78458) with an affinity constant of 8.072E-10 M as determined in BLI assay.

  • Ganitumab Chemical Structure
    1/16
  • Ganitumab
  • Flow cytometric analysis of 1X106 MCF-7 cells with Ganitumab (HY-P99294, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.
  • Loaded Ganitumab on AHC2 biosensor, can bind IGF-I R Protein, Human (HEK293, His-Avi, HY-P78458) with an affinity constant of 8.072E-10 M as determined in BLI assay.