EREG - epiregulin Gene

Also Known as ER; Ep; EPR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2069

About EREG

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,365,145-74,388,749 (from NCBI)

This gene has 3 transcripts (splice variants), 138 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 51.6), esophagus (RPKM 7.6) and 3 other tissues.

Summary

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

EREG Products (1)

mRNA	Protein	Name
NM_001432.3	NP_001423.1	proepiregulin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9419975	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	9556621	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	9556621	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in ERBB2-EGFR signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	14581411	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	9419975	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in keratinocyte proliferation	IDA IDA: Inferred from direct assay	10681561	GOA
involved in mRNA transcription	IDA IDA: Inferred from direct assay	10681561	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14581411	GOA
involved in negative regulation of smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	14581411	GOA
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	9337852	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10681561	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	10681561	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	12702554	GOA
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	9419975	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	14581411	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	9556621	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	9337852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
proepiregulin

EREG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	EREG	O14944	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	EREG	O14944	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	EREG	O14944	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	EREG	O14944	EGFR	Homo sapiens	P00533	SAXS	28988771
Intra	EREG	O14944	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EREG Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7011	Epiregulin Protein, Human	O14944 (V60-L108)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73031	Epiregulin Protein, Human (HEK293, Fc)	O14944/NP_001423.1 (V63-L108)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Histiocytoma, Malignant Fibrous Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Fibrous, Malignant
Squamous Blepharitis
Vallecula Cancer	Malignant Tumor Of Vallecula
Bronchiectasis 2
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Mixed Cell Adenoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04487	EREG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16966	Ereg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174716	Human EREG mRNA		/	Unkown
HY-RS23409	Ereg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P992137	Turigrobart	Inhibitor	99.9%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EREG	VGNC	VGNC:106572
Felis catus	EREG	VGNC	VGNC:61935
Rattus norvegicus	EREG	RGD	RGD:620299
Mus musculus	EREG	MGD	MGI:107508
Bos taurus	EREG	VGNC	VGNC:28575
Others	EREG	NCBI