NAV2 - neuron navigator 2 Gene

Also Known as HELAD1; RAINB1; POMFIL2; UNC53H2; STEERIN2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89797

About NAV2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,345,236-20,121,601 (from NCBI)

This gene has 15 transcripts (splice variants), 242 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 4.0), brain (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NAV2 Products (5)

mRNA Protein Name
NM_001111018.2 NP_001104488.1 neuron navigator 2 isoform 3
NM_001111019.3 NP_001104489.1 neuron navigator 2 isoform 4
NM_001244963.2 NP_001231892.1 neuron navigator 2 isoform 5
NM_145117.5 NP_660093.2 neuron navigator 2 isoform 2
NM_182964.6 NP_892009.3 neuron navigator 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables 3'-5' DNA helicase activity IDA
IDA: Inferred from direct assay
12214280 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAV2 Protein Structure

CH

CH: Calponin homology (CH) domain (91 - 190)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2488 a.a.
Protein Preferred Names Protein Names

neuron navigator 2

  • helicase, APC down-regulated 1

NAV2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NAV2 Q8IVL1 CFAP58 Homo sapiens Q5T655
Y2H Array
25416956
Intra
NAV2 Q8IVL1 RBM15B Homo sapiens Q8NDT2-2
Y2H Array
25416956
Intra
NAV2 Q8IVL1 RBM15B Homo sapiens Q8NDT2-2
Y2H Prey Pooling
25416956
Intra
NAV2 Q8IVL1 RBM15 Homo sapiens Q96T37
Y2H Array
25416956
Intra
NAV2 Q8IVL1 ADAT2 Homo sapiens Q7Z6V5
Y2H Prey Pooling
25416956
Intra
NAV2 Q8IVL1 ADAT2 Homo sapiens Q7Z6V5
Validated Y2H
25416956
Intra
NAV2 Q8IVL1 ADAT2 Homo sapiens Q7Z6V5
Y2H Array
25416956
Intra
NAV2 Q8IVL1 ING4 Homo sapiens Q9UNL4
Y2H Array
25416956
Intra
NAV2 Q8IVL1 ING4 Homo sapiens Q9UNL4
Validated Y2H
25416956
Intra
NAV2 Q8IVL1 PIAS2 Homo sapiens O75928
Y2H Array
25416956
Intra
NAV2 Q8IVL1 MORF4L1 Homo sapiens Q9UBU8
Y2H Prey Pooling
25416956
Intra
NAV2 Q8IVL1 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
Intra
NAV2 Q8IVL1 ING5 Homo sapiens Q8WYH8
Validated Y2H
25416956
Intra
NAV2 Q8IVL1 RBM15B Homo sapiens Q8NDT2
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuroblastoma 1

  • Neuroblastoma, Susceptibility To, 1

  • NBLST1

  • Neuroblastoma, Susceptibility To, Type 1
Sucrase-Isomaltase Deficiency, Congenital

  • Congenital Sucrase-Isomaltase Deficiency

  • CSID

  • Si Deficiency

  • Congenital Sucrose Intolerance

  • Disaccharide Intolerance

  • Sucrase-Isomaltase Deficiency

  • Disaccharide Intolerance I

  • Congenital Sucrose-Isomaltose Malabsorption

  • Sucrose-Isomaltose Malabsorption, Congenital

  • Sucrose Intolerance, Congenital

  • Congenital Sucrase-Isomaltose Malabsorption

  • Congenital Sucrose-Isomaltase Malabsorption

  • Disaccharide Intolerance, 1

  • Sucrose Intolerance Congenital

  • Sucrose-Isomaltase Malabsorption, Congenital

  • Disaccharidase Deficiency

  • Invertase Deficiency

  • Sucrase-Alpha-Dextrinase Deficiency

  • Disaccharide Intolerance Type I

  • Csid - [Congenital Sucrase-Isomaltase Deficiency]

  • Sucrose Intolerance Of Newborn

  • Sucrose Intolerance

  • Sucrase Deficiency

  • Disaccharide Malabsorption

  • Intestinal Disaccharidase Deficiency
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09047 NAV2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NAV2 VGNC VGNC:74968
Felis catus NAV2 VGNC VGNC:81976
Bos taurus NAV2 VGNC VGNC:31891
Mus musculus NAV2 MGD MGI:2183691
Canis familiaris NAV2 VGNC VGNC:43630
Rattus norvegicus NAV2 RGD RGD:619778
Others NAV2 NCBI