Glenthmycin A
Glenthmycin A is a macrocyclic type II spiroketal polyketide antibacterial agent. Glenthmycin A inhibits the growth of Gram-positive pathogens. Glenthmycin A is applicable to the research of bacterial infections.
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- CAS No.: 3040055-59-9
- Formule: C49H63NO13
- Masse moléculaire:874.04
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Glenthmycin A (Compound 1) (0.01-30 μM; 16-24 h) inhibits the growth of S. aureus ATCC 25923 (IC50 6.4 μM), E. faecalis (IC50 5.7 μM), MRSA ATCC 43300 (IC50 4.4 μM), MRSA ATCC 33591 (IC50 1.9 μM), and VRE (IC50 5.2 μM)[1].
Glenthmycin A (30 μM; 48 h) does not exhibit significant cytotoxicity against human colorectal carcinoma (SW620) or human lung carcinoma (NCI-H460) cells, with IC50 > 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3040055-59-9
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Masse moléculaire 874.04
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Formule C49H63NO13
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SMILES
OC=1[C@@]23[C@@](C=C(C(O)=O)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](O[C@H]6[C@H](O)[C@](C)(O)[C@H](NC(=O)C7=C(C)C=C(OC)C=C7O)[C@@H](C)O6)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
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Structure Classification
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Initial Source
Streptomyces sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)