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Cat. No.: HY-162525

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GS-9770

GS-9770 is an orally active inhibitor for HIV protease with K_i of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC₅₀ of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats.

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CAS No.: 2306328-43-6
Formule: C₃₅H₃₄ClF₇N₁₀O₃
Masse moléculaire:811.15

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

GS-9770 Chemical Structure

CAS No.: 2306328-43-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 2306328-43-6
Masse moléculaire 811.15
Formule C₃₅H₃₄ClF₇N₁₀O₃
SMILES

CC(C(F)(F)F)(C[C@@]1(C2=CC=C(C=C2)C3=NN(N=C3)C4CC4)C(N(C(N1)=N)[C@@H](C5=CC=C(C(C6=NC=NN6C(F)F)=C5)Cl)COC(NC7(C(F)F)CC7)=O)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mulato A, et al., Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0137323. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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