HS56
Based on 1 Customer Validation
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.6%
- CAS No.: 922050-57-5
- Formule: C13H8ClN5OS
- Masse moléculaire:317.75
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Activité biologique
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PIM3 0.208 μM (Ki) |
PIM1 2.94 μM (Ki) |
PIM2 ＞100 μM (Ki) |
HS56 (50 μM; 16 h) delays force onset, decreases contractile force, and reduces LC20 phosphorylation in excised rat caudal arterial VSM tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:VSM tissues
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Concentration:50 μM
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Incubation Time:16 hours
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Result:Modulated LC20 phosphorylation in VSM tissues.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Spontaneously hypertensive renin transgene and wild-type (WT) mice[1]
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Dosage:10 and 20 mg/kg
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Administration:Intravenous injection, single injection
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Result:Induced dose-dependent decreases in systolic blood pressure.
Chemical Information
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CAS No. 922050-57-5
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Appearance Solid
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Masse moléculaire 317.75
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Formule C13H8ClN5OS
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Color White to off-white
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SMILES
N#CCSC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HS56 Related Classifications
HY-123983 Related Classifications
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