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Adakitug

(Synonyms: BMS-986253; HuMax-IL-8)
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Adakitug (BMS-986253) is a CHO-expressed human antibody targeting CXCL8/IL-8. Adakitug contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 144.94 kDa. The isotype control for Adakitug can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Adakitug exhibits anti-tumor activity and can be applied in tumor research.

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  • Pureté: ≥99.0%
  • CAS No.: 2231258-73-2
  • Masse moléculaire:144.94 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Adakitug
  • Experimental Validation Results for Adakitug
  • Experimental Validation Results for Adakitug
  • Experimental Validation Results for Adakitug
  • Adakitug Chemical Structure
  • Experimental Validation Results for Adakitug
  • Experimental Validation Results for Adakitug
  • Experimental Validation Results for Adakitug
  • Experimental Validation Results for Adakitug
  • Adakitug Chemical Structure
    Adakitug Chemical Structure
CAS No.: 2231258-73-2
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Flow cytometric analysis of 1X106 HUVEC cells with Adakitug (HY-P990598, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized IL-8/CXCL8 Protein, Human can bind Adakitug. The EC50 for this effect is 43.97 ng/mL.

  • 1/16

    Loaded Adakitug on AHC2 biosensor, can bind HY-P7224 IL-8/CXCL8 Protein, Human with an affinity constant of <1.0E-11 M as determined in BLI assay.

  • Adakitug Chemical Structure
    1/16
  • Adakitug
  • Flow cytometric analysis of 1X106 HUVEC cells with Adakitug (HY-P990598, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized IL-8/CXCL8 Protein, Human can bind Adakitug. The EC50 for this effect is 43.97 ng/mL.
  • Loaded Adakitug on AHC2 biosensor, can bind HY-P7224 IL-8/CXCL8 Protein, Human with an affinity constant of <1.0E-11 M as determined in BLI assay.
  • IgG1-kappa