KR31173
KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice.
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- CAS No.: 260554-07-2
- Formule: C31H30N8O2
- Masse moléculaire:546.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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AT1 Receptor 3.27 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice were injected via the tail vein with 19.1 MBq (517 μCi, 1.45 μg/kg) of [11C] KR31173 10 min after KR31173 administration[1].
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Dosage:1 mg/kg
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Administration:i.v., once and then collected blood sample, and measured organs weight and their radioactivity 60 min after [11C] KR31173 administration.
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Result:Had high initial liver uptake which rapidly washes out over 30 minutes following by subsequent accumulation in adrenal glands and kidneys after 30 minutes, with tissue-to-blood ratios generally exceeding 10:1.
Significantly inhibited the uptake of [11C] KR31173 in the adrenal glands (91%), kidneys (90%), lungs (88%), heart (92%) and livers (50%).
Chemical Information
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CAS No. 260554-07-2
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Masse moléculaire 546.62
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Formule C31H30N8O2
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SMILES
[O-][N+]1=CC=CC=C1C2=C(COC)N=C(N(CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C(CCCC)=N6)C6=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KR31173 Related Classifications
HY-165425 Related Classifications
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