LY580276
LY580276 is an ATP-competitive ALK5 inhibitor with an IC50 of 175 nM. LY580276 inhibits transforming growth factor-β-induced epithelial-mesenchymal transition. LY580276 can be used for cancer research.
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- CAS No.: 476475-07-7
- Formule: C18H16FN3
- Masse moléculaire:293.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
0.339 μM
Compound: 15
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Inhibitory activity tested in NIH 3T3 cells
Inhibitory activity tested in NIH 3T3 cells
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[PMID: 15177480] |
LY580276 potently and selectively inhibits ALK5 kinase activity with an IC50 of 175 nM, blocks TGF-β-mediated cellular signalling with an IC50 of 96 nM, and shows minimal activity against p38 MAP kinase (IC50 >10 μM)[1].
LY580276 (2 μM) inhibits TGF-β-induced epithelial-to-mesenchymal transition in normal murine mammary epithelial (NMuMG) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 476475-07-7
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Masse moléculaire 293.34
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Formule C18H16FN3
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SMILES
FC1=CC=C(C2=C(CCC3)N3N=C2C4=CC=CC(C)=N4)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY580276 Related Classifications
HY-182547 Related Classifications
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