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Cat. No.: HY-155011

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MB076

MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with K_i values <1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(-) susceptibility.

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CAS No.: 2832966-95-5
Formule: C₉H₁₂BN₇O₅S₂
Masse moléculaire:373.18

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MB076 Chemical Structure

CAS No.: 2832966-95-5

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Description

IC₅₀ & Target

Ki Target: ADC-7, ADC-30, ADC-162, ADC-33, ADC-219, ADC-212^[1]
Ki: 0.21±0.016 μM (ADC-7), 0.058±0.005μM (ADC-30), 0.79±0.039μM (ADC-162), 0.10±0.004μM (ADC-33), 0.11±0.019 (ADC-219), 0.61±0.038μM (ADC-212)^[1]

In Vitro

MB076 (compound B) (0.5-5 μM, 48 h) has an improved stability in human plasma^[1].
MB076 (10 μg/mL, 48 h) acts synergistically in combination with Ceftazidime (CAZ, HY-B0593), and Cefotaxime (CTX, HY-A0088A) to restore pBCSK(−) susceptibility^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human Plasma
Concentration:

0.5 μM, 1 μM, 2.5 μM, 4 μM, 5 μM
Incubation Time:

48 h
Result:

Showed excellent stability in human plasma, with a t_1/2 value of 29 h, notably higher than the value obtained for ADC-7/S02030 (PDB4U0X) (9 h).

Chemical Information

CAS No. 2832966-95-5

Masse moléculaire 373.18

Formule C₉H₁₂BN₇O₅S₂

SMILES

NC1=NN=C(SCC(N[C@H](B(O)O)CN2C=C(C(O)=O)N=N2)=O)S1

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Rachel A. Powers, et al. Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J Med Chem. 2023 Jul 13; 66(13): 8510–8525.

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Calculateur de dilution

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MB076 Related Classifications

HY-155011 Related Classifications

Anti-infection

Bacterial

Aires thérapeutique

Infection

Infection

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Keywords

MB076
2832966-95-5
MB 076
MB-076
Bacterial
Inhibitor
inhibitor
inhibit

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