Methoxy-SANT-2
Methoxy-SANT-2 (TC-132) is a potent hedgehog antagonist with an IC50 value of 79.8 nM. Methoxy-SANT-2 inhibits the Gli1 reporter gene expression. Methoxy-SANT-2 has the potential for the research of cancer.
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- CAS No.: 496793-78-3
- Formule: C23H20ClN3O4
- Masse moléculaire:437.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Shh Light II | IC50 |
79.8 nM
Compound: 7, TC132
|
Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG
Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG
|
[PMID: 19541490] |
Chemical Information
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CAS No. 496793-78-3
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Masse moléculaire 437.88
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Formule C23H20ClN3O4
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SMILES
COC1=C(C(OC)=CC(C(NC2=CC(C3=NC4=C(N3)C=CC=C4)=C(C=C2)Cl)=O)=C1)OC
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Synonyms
TC-132
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)