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Cat. No.: HY-12689S

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Mitapivat-d₈

(Synonyms: AG-348-d₈)

Mitapivat-d₈ (AG-348-d₈) is the deuterium labeled Mitapivat (HY-12689). Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency.

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Formule: C₂₄H₁₈D₈N₄O₃S
Masse moléculaire:458.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mitapivat-d₈ Chemical Structure

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Activité biologique
- Description
- In Vitro
- Application
Chemical Information
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Bioz

Activité biologique

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 1260075-17-9
Masse moléculaire 458.60
Formule C₂₄H₁₈D₈N₄O₃S
SMILES

O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4C([2H])([2H])C([2H])([2H])N(CC5CC5)C([2H])([2H])C4([2H])[2H])=O)C=C3)=O
Synonyms

AG-348-d₈
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.