MK771
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.
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- CAS No.: 66537-55-1
- Formule: C16H22N6O4S
- Masse moléculaire:394.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
MK771 (10 ng-10 µg/mouse; i.c.v.) produces a hyperthermic response in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-30 g, male MF1 mice[1]
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Dosage:5 mg/kg
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Administration:I.p.
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Result:Induced blinking and forepaw licking in both acutely isolated and paired mice.
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Animal Model:20-30 g, male MF1 mice[1]
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Dosage:0.25-60 mg/kg
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Administration:I.p.
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Result:Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg.
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Animal Model:25-30 g, Male Swiss-Webster mice[2]
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Dosage:10 ng-10 µg/mouse
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Administration:I.c.v.
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Result:Produced a hyperthermic response for 4 h followed by a return to normal temperature.
Chemical Information
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CAS No. 66537-55-1
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Masse moléculaire 394.45
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Formule C16H22N6O4S
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SMILES
O=C(N[C@H](C(N1CSC[C@@H]1C(N)=O)=O)CC2=CNC=N2)[C@@H](N3)CCCC3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Pureté et documentation
Références
[1]. McCreary AC, et al. The thyrotrophin-releasing hormone analogue MK771 induces tic-like behaviours: the effects of dopamine D1 and D2 receptor antagonists. Eur J Pharmacol. 1999 Mar 12;369(1):1-9. [Content Brief]
[2]. Bhargava HN, et al. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl). 1985;87(2):141-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK771 Related Classifications
HY-119174 Related Classifications
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