MRS4719
MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.
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- CAS No.: 2840581-32-8
- Formule: C26H13N5O3S.C6H15N
- Masse moléculaire:504.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
IC50: 0.503 μM (P2X4 receptor)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:0.5, 1.5 and 3 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Caused significant neuroprotection using total hemispheric infarct volume size at doses 1.5 and 3.0 mg/kg.
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Animal Model:Middle-aged C57B/6 mice (11-12 month-old; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:1.5 and 3 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Did not improve motor coordination and balance as assessed using rotarod.
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Animal Model:Middle-aged C57B/6 mice (11-12 month-old; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:3 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Improved dose-dependently learning and memory after stroke and reached statistical significance at a dose of 3 mg/kg.
Chemical Information
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CAS No. 2840581-32-8
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Masse moléculaire 504.60
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Formule C26H13N5O3S.C6H15N
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SMILES
CC[NH+](CC)CC.O=C(NC1=C2C=CC=CC2=CC=C1N3C4=CC(C([N-]5)=NOC5=S)=NC=C4)CC3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRS4719 Related Classifications
HY-151547 Related Classifications
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