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Cat. No.: HY-122176

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NU-7107

NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ >10 μM. NU-7107 is applicable for cancer research.

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CAS No.: 503465-21-2
Formule: C₁₈H₁₉N₃O₂
Masse moléculaire:309.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NU-7107 Chemical Structure

CAS No.: 503465-21-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ >10 μM. NU-7107 is applicable for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	3.25 μM Compound: 94	Inhibition of DNA dependent protein kinase isolated from HeLa cells Inhibition of DNA dependent protein kinase isolated from HeLa cells	[PMID: 15658870]

In Vitro

NU7107 weakly inhibits DNA-PK with an IC₅₀ of >10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2	V_d
Mice^[1]	20 mg/kg	i.p.	10390 nM	0.25 h	0.79 h	0.12 L

In Vivo

NU-7107 (20 mg/kg; i.p.; single administration) exhibits significantly improved in vivo pharmacokinetic properties compared with NU7026 in female BALB/c mice, with a 4-fold lower plasma clearance rate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female)^[1]
Dosage:

20 mg/kg
Administration:

i.p.; single dose
Result:

Reached a maximum plasma concentration (C_max) of 10390 nmol/L.
Reached time to maximum concentration (T_max) of 0.25 h.
Achieved area under the concentration vs time curve (AUC_last) of 12165 nmol·h/L.
Had a terminal half-life (t1/2) of 0.79 h.
Had plasma clearance (CI _obs.) of 0.11 L/h.
Had volume of distribution (V_d) of 0.12 L.
Remained detectable in plasma 6 hours post-administration.
Exhibited plasma clearance four-fold slower than that of NU7026.

Chemical Information

CAS No. 503465-21-2
Masse moléculaire 309.37
Formule C₁₈H₁₉N₃O₂
SMILES

O=C1N2C(C=3C(C=C2)=CC=CC3)=NC(=C1)N4C[C@H](C)O[C@H](C)C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Nutley BP, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005;93(9):1011-1018. [Content Brief]

Calculators

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Molecular Weight Molecular Weight

Calculateur de dilution

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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