Nuclear localizing sequence
Nuclear localizing sequence is a peptide sequence that functions as an inducer and exhibits membrane permeability in mammalian cells. Nuclear localizing sequence enhances cellular uptake and directs conjugated ruthenium (II) complexes to the nucleus for nuclear DNA imaging.
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- CAS No.: 503474-42-8
- Formule: C55H103N21O12S
- Masse moléculaire:1282.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
The nuclear localizing sequence (Compound 12a) targets the conjugated [Ru (bpy)2 (dppz)]2+ complex to the cell nucleus, and enables selective imaging of nuclear DNA by virtue of the "light-switch" emission behavior of this complex[1].
Conjugation of the nuclear localizing sequence with a ruthenium (II) biquinoline complex bearing perchlorate counterions enables efficient cellular uptake in CHO and HeLa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 503474-42-8
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Masse moléculaire 1282.60
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Formule C55H103N21O12S
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Sequence
Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-NH2
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Sequence Shortening
VQRKRQKLMP-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lee LC, et al. Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications. J Am Chem Soc. 2022;144(32):14420-14440. [Content Brief]
[2]. Cullinane D, et al. Photostable NIR emitting ruthenium(II) conjugates; uptake and biological activity in live cells. J Inorg Biochem. 2020;207:111032. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nuclear localizing sequence Related Classifications
HY-P11744 Related Classifications
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