ppTG21
ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 380480-77-3
- Formule: C115H173N31O22
- Masse moléculaire:2341.80
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
ppTG21 (7.5 nmol ppTG21 salt; 44-48 h) facilitates endosomal escape of Cas9-2lig-1NLS RNP, leading to cell-type specific gene editing with 4.8% indels in HEPG2 cells (ASGPr+); negligible editing occurs in SKHEP cells (ASGPr diminished) with either RNP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 380480-77-3
-
Masse moléculaire 2341.80
-
Formule C115H173N31O22
-
Sequence
Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala
-
Sequence Shortening
GLFHALLHLLHSLWHLLLHA
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz