ULK
ULK kinases are the mammalian orthologs of yeast Atg1 and initiate autophagy. ULK1 and ULK2 assemble with FIP200 (RB1CC1), ATG13 and ATG101 into a complex that is inhibited by mTORC1 phosphorylation in nutrient-rich conditions and activated by AMPK when energy is scarce. Activated ULK1 phosphorylates Beclin-1, ATG9, ATG14 and AMBRA1 to nucleate the phagophore. The family also includes ULK3, which acts in Hedgehog signaling through GLI proteins, ULK4, a divergent member with reduced catalytic consensus that is brain-enriched and linked to neurodevelopmental disorders, and the distantly related STK36. The clinical ULK1 inhibitor DCC-3116 tests autophagy blockade in RAS-driven tumors.
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ULK Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
