RAF-IN-1
Based on 2 publication(s) in Google Scholar
RAF-IN-1 is a RAF inhibitor with IC50 values of 29.4 nM, 3.8 nM, and 36 nM against human recombinant bRAFV600E, cRAF, and bRAFWT enzymes, respectively. RAF-IN-1 suppresses RAF enzymatic activity and reduces cancer cell proliferation. RAF-IN-1 can be used for cancer research.
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- CAS No.: 2695505-82-7
- Formule: C26H22F3N3O4
- Masse moléculaire:497.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) RAF-IN-1
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Activité biologique
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BRafV600E 29.4 nM (IC50) |
BRAFWT 36 nM (IC50) |
C-Raf 3.8 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| A-375 | GI50 |
2.9 μM
Compound: 9
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Growth inhibition of human A375 cells expressing bRaf V600E mutant measured after 3 days by Cell-titer Glo assay
Growth inhibition of human A375 cells expressing bRaf V600E mutant measured after 3 days by Cell-titer Glo assay
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[PMID: 35276360] |
| Calu-6 | GI50 |
3.9 μM
Compound: 9
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Growth inhibition of human Calu-6 cells expressing KRAS Q61K mutant measured after 3 days by Cell-titer Glo assay
Growth inhibition of human Calu-6 cells expressing KRAS Q61K mutant measured after 3 days by Cell-titer Glo assay
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[PMID: 35276360] |
| NCI-H358 | GI50 |
3.4 μM
Compound: 9
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Growth inhibition of human H358 cells expressing KRAS G21C mutant measured after 3 days by Cell-titer Glo assay
Growth inhibition of human H358 cells expressing KRAS G21C mutant measured after 3 days by Cell-titer Glo assay
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[PMID: 35276360] |
RAF-IN-1 (Compound 1) (1 h) potently inhibits purified human recombinant bRAFV600E enzyme with an IC50 of 29.4 nM[1].
RAF-IN-1 potently inhibits purified human recombinant cRAF enzyme with an IC50 of 3.8 nM[1].
RAF-IN-1 inhibits purified human recombinant bRAFWT enzyme with an IC50 of 36 nM[1].
RAF-IN-1 potently inhibits proliferation of KRASG12C mutant H358 human non-small cell lung cancer cells with a GI50 of 3.4 μM and minimized paradoxical activation[1].
RAF-IN-1 inhibits proliferation of bRAFV600E mutant A375 human melanoma cells with a GI50 of 2.9 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2695505-82-7
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Masse moléculaire 497.47
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Formule C26H22F3N3O4
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SMILES
O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC4=C(C(NC5(CCOCC5)O4)=O)C=C3)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Phytother Res
(+)-Matairesinol, Derived From Olive Oil, Enhanced T-Cell Anti-Tumor Immune via JAK3-STAT1 Signal and Synergized With Anti-PD-1 Efficacy. [Abstract]2026 Apr 27. PMID: 42037203 -
J Ethnopharmacol
"Shihu" promote T-cell immunity against breast cancer through bioactive constituent THMB enhancing JAK3-STAT1 signal. [Abstract]2026 Oct 28:369:121888. PMID: 42202911
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RAF-IN-1 Related Classifications
HY-144271 Related Classifications
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