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Cat. No.: HY-187922

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Rufutalkib

Rufutalkib is an orally active ALK modulator. It possesses thermodynamic and chemical stability, and can be used in research related to anaplastic large cell lymphoma, non-Hodgkin's lymphoma, inflammatory myofibroblastic tumor, neuroblastoma, glioblastoma, and ALK-positive malignancies.

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CAS No.: 1609170-61-7
Formule: C₂₉H₃₆ClN₅O₃S
Masse moléculaire:570.15

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rufutalkib Chemical Structure

CAS No.: 1609170-61-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Rufutalkib succinate Form VI is hygroscopic with a 5.4% weight gain at 80% RH, and converts to an amorphous state after moisture sorption testing^[1].
Rufutalkib succinate Form VI has high solubility in simulated gastric fluid (7.34-7.35 mg/mL) and low solubility in fasted-state simulated intestinal fluid (0.10 mg/mL) over a 4-hour period at 37°C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-t	T_1/2	Bioavailability
Rat^[1]	1 mg/kg	i.g.	3 h	168 ng/mL	2810 ng·h/mL	7.55 h	69.0 %
Rat^[1]	2 mg/kg	i.g.	4 h	322 ng/mL	6164 ng·h/mL	8.39 h	/
Rat^[1]	4 mg/kg	i.g.	4 h	451 ng/mL	10043 ng·h/mL	8.31 h	/
Rat^[1]	1 mg/kg	i.v.	/	/	4071 ng·h/mL	7.23 h	/

In Vivo

Rufutalkib (1-4 mg/kg; i.v., i.g.; single dose) demonstrates high oral bioavailability of approximately 69.0% in rats, with dose-dependent exposure following single i.g. administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1609170-61-7
Masse moléculaire 570.15
Formule C₂₉H₃₆ClN₅O₃S
SMILES

CC1=CC(NC2=NC=C(Cl)C(NC3=C(C=CC=C3)S(C(C)C)(=O)=O)=N2)=C4C(C[C@H](O4)C)=C1C5CCN(CC5)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang K Y, et al. Crystal form of alk inhibitor. WO2025040026A1. World Intellectual Property Organization. 2025-02-27.

[2]. Wang W, et al. Certain protein kinase inhibitors. US20140128387A1. United States Patent and Trademark Office. 2014-05-08.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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