San45
San45 is a nonselective dual amylin and calcitonin receptor agonist (DACRA) with nonselective potency relative to calcitonin receptor (CTR) and amylin 1 receptor (AMY₁R), and acts as a stabilizer of receptor-ligand complex and prolonged activator of cAMP signaling. San45 carries a conjugated lipid modification that can be used for the research of obesity.
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- Formule: C194H309N51O57S2
- Masse moléculaire:4331.97
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
San45 (serial dilutions; 30 min) is a potent, nonselective dual amylin and calcitonin receptor agonist (DACRA) with similar potency at AMY3R (pEC50 = 10.66) and CTR (pEC50 = 10.45) in HEK293-Flp-In cells[1].
San45 (serial dilutions; 30 min) maintains potent, nonselective DACRA activity across CTR, AMY1R, and AMY3R in COS-1 cells, with pEC50 values of 9.19 (CTR), 8.83 (AMY1R), and 9.34 (AMY3R)[1].
San45 (4 μM (AMY3R complex); 2 μM (CTR complex)) binds to AMY3R via a distorted bypass conformation and to CTR via an alternative CT-like conformation, stabilized by its lipid modification, supporting its nonselective DACRA activity[1].
San45 (serial dilutions; measured over cycles) exhibits prolonged cAMP signaling duration in COS-7 cells expressing AMY1R, likely due to its lipid modification[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 4331.97
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Formule C194H309N51O57S2
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Sequence
Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Lys(γGlu-C16 acid)-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr (Disulfide bridge:Cys2-Cys7)
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Sequence Shortening
KCNTATCATQRLANFLVHSS-Lys(γGlu-C16 acid)-NFGPILPPTNVGSNTY (Disulfide bridge:Cys2-Cys7)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
San45 Related Classifications
HY-P11586 Related Classifications
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