Sarmentogenin
Sarmentogenin is a cardenolide aglycone can be found in rhodexin A and Chrysolina herbacea.
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- CAS No.: 76-28-8
- Formule: C23H34O5
- Masse moléculaire:390.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | Inhibition |
105.751 %
Compound: SARMENTOGENIN
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Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
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[PMID: 23571415] |
| CHO | Inhibition |
70.5845 %
Compound: SARMENTOGENIN
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Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
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[PMID: 23571415] |
| HCT-116 | Survival |
26 %
Compound: sarmentogenin
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Cytotoxicity against human HCT116 cells assessed as survival index at 10 uM after 72 hrs by FMCA method
Cytotoxicity against human HCT116 cells assessed as survival index at 10 uM after 72 hrs by FMCA method
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[PMID: 19894733] |
| HT-29 | Survival |
63 %
Compound: sarmentogenin
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Cytotoxicity against human HT-29 cells assessed as survival index at 10 uM after 72 hrs by FMCA method
Cytotoxicity against human HT-29 cells assessed as survival index at 10 uM after 72 hrs by FMCA method
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[PMID: 19894733] |
Chemical Information
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CAS No. 76-28-8
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Masse moléculaire 390.51
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Formule C23H34O5
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SMILES
C[C@@]12[C@@]([C@@]3([H])[C@]([C@@]4([C@](C[C@H](CC4)O)([H])CC3)C)([H])[C@@H](C1)O)(CC[C@@H]2C(CO5)=CC5=O)O
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Structure Classification
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Initial Source
Chrysolina herbacea
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Song F, et al. Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin. Beilstein J Org Chem. 2025;21:2637-2644. Published 2025 Dec 3. [Content Brief]
[2]. Pasteels JM, et al. Cardiac glycosides in the defensive secretion of Chrysolina herbacea (Coleoptera, Chrysomelidae). Identification, biological role and pharmacological activity. Comp Biochem Physiol C Comp Pharmacol. 1979;63C(1):117-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarmentogenin Related Classifications
HY-N14147 Related Classifications
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