Cat. No.: HY-L010

MAPK Compound Library

88 Cited Publications

Avis client

Based on 88 publication(s) in Google Scholar

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 1,112 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

PDF
Excel
SDF
Manual

Size

Prix

Stock

Quantité

In-stock

(2-3 weeks)

Get a Quotation Now

In-stock

(2-3 weeks)

Get a Quotation Now

(2-3 weeks)

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (88)
Documentation
Composition

Description & Advantages

• A unique collection of 1,112 MAPK signaling inhibitors for high throughput screening (HTS) and high content screening (HCS).

• Targets such as ERK, JNK, MEK, p38 MAPK, Raf, RSK, etc.

• A useful tool for MAPK-related drug discovery and disease research.

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

• Structurally diverse, medicinally active, and cell permeable.

• More detailed compound information with structure, IC₅₀, and brief introduction.

• NMR and HPLC validated to ensure high purity and quality.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 1,112 MAPK/ERK signaling related compounds supplied as pre-dissolved Solutions or Solid

Solution: 1,074 compounds supplied in 10 mM solution, 36 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice