Setrusumab
Based on 1 Customer Validation
Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.9%
- CAS No.: 1847394-95-9
- Masse moléculaire:143.44 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human IgG2 lambda
Human
SOST/Sclerostin
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old female immune-compromised CB-17/lcr-Prkdcscid/Rj mice with MDA-MB-231 breast cancer cells injection[1]
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Dosage:100 mg/kg
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Administration:Intravenous injection; 100 mg/kg once a week for 4 weeks
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Result:Significantly inhibited tumor growth in bones and breast cancer cell dissemination into other organs. Inhibited breast cancer-induced osteolytic lesions and subsequent loss of bone mass of the distal femur and of the proximal tibia. Redued phosphorylation of IKKα, IKKβ, and p65.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 lambda
ELISA, FACS, Functional assay
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Loaded Setrusumab on AHC2 biosensor, can bind SOST Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78209) with an affinity constant of 8.123E-11 M as determined in BLI assay. -
Immobilized SOST Protein, Human (HEK293, His, HY-P70756) can bind Setrusumab. The EC50 for this effect is 12.07 ng/mL.
Chemical Information
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CAS No. 1847394-95-9
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Appearance Liquid
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Masse moléculaire 143.44 kDa
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Color Colorless to light yellow
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SMILES
[Setrusumab]
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Synonyms
BPS 804
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Setrusumab Related Classifications
HY-P99398 Related Classifications
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