SKLB-C05
SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer.
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- CAS No.: 2300981-68-2
- Formule: C23H23ClN2O2
- Masse moléculaire:394.89
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.5 nM[1]
Chemical Information
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CAS No. 2300981-68-2
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Masse moléculaire 394.89
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Formule C23H23ClN2O2
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SMILES
O=C1NC2=C(C)C=C(O)C(C3=CC=C(C=C3)[C@H](CN)C)=C2C4=C1C=CC=C4.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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