Tabernanthine
Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences.
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- CAS No.: 83-94-3
- Formule: C20H26N2O
- Masse moléculaire:310.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Chemical Information
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CAS No. 83-94-3
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Masse moléculaire 310.43
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Formule C20H26N2O
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SMILES
CC[C@@H]1[C@@]2([H])[C@]3([H])C4=C(CC[N@]2C[C@@](C1)([H])C3)C5=CC=C(OC)C=C5N4
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Zetler G, et al. Die Wirkung von 11 Indol-Alkaloiden auf das Meerschweinchen-Herz in vivo und in vitro, verglichen mit 2 synthetischen Azepinoindolen, Chinidin und Quindonium [Action of 11 indole alkaloids on the guinea pig heart in vivo and in vitro, compared with those of 2 synthetic azepinoindoles, quinidine and quindonium]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968 May 7;260(1):26-49. German. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)