TIM-098a
TIM-098a is a selective AAK1 inhibitor with an IC50 of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity.
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- Formule: C18H11N3O2
- Masse moléculaire:301.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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AAK1 0.24 μM (IC50) |
GAK 1.04 μM (IC50) |
BIKE 5.99 μM (IC50) |
STK16 7.15 μM (IC50) |
TIM-098a can inhibit AAK1 activity in transfected cultured cells (IC50=0.87 µM)[1].
TIM-098a (0.26, 0.82, 2.6, 26 μM; for 6 h) suppresses AAK1-catalyzed Thr156 phosphorylation of GST-AP2µ2 (145-162) in a concentration-dependent manner in AAK1/GST-AP2µ2 (145-162) expressing COS-7 cells[1].
TIM-098a (10 μM; for 6 h) recovers the number of early endosomes in AAK1-transfected cells to the level of untransfected wild type cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 301.30
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Formule C18H11N3O2
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SMILES
O=C(C1=CC=CC2=CC(O)=CC3=C12)N4C3=NC5=CC(N)=CC=C54
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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