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Cat. No.: HY-W795993

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TJU103

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4⁺ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research.

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CAS No.: 10245-44-0
Formule: C₁₅H₁₂N₄O
Masse moléculaire:264.28

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

TJU103 Chemical Structure

CAS No.: 10245-44-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HEL	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HEL	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against TK(-) aciclovir-resistant Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against TK(-) aciclovir-resistant Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HEL	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HeLa	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HeLa	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HeLa	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
MT4	CC₅₀	95 μg/mL Compound: 8	Cytotoxicity against Homo sapiens (human) MT4 cells Cytotoxicity against Homo sapiens (human) MT4 cells	10.1007/s00044-011-9662-9
MT4	EC₅₀	>95 μg/mL Compound: 8	Antiviral activity against Human immunodeficiency virus 1 IIIB infected human MT4 cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human immunodeficiency virus 1 IIIB infected human MT4 cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
MT4	EC₅₀	>95 μg/mL Compound: 8	Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) infected human MT4 cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) infected human MT4 cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Punta Toro virus infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Punta Toro virus infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>100 μg/mL Compound: 8	Antiviral activity against Sindbis virus infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Sindbis virus infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	2.4 μg/mL Compound: 8	Antiviral activity against Mammalian orthoreovirus 1 infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Mammalian orthoreovirus 1 infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	45 μg/mL Compound: 8	Antiviral activity against Human coxsackievirus B4 infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human coxsackievirus B4 infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9

Chemical Information

CAS No. 10245-44-0
Masse moléculaire 264.28
Formule C₁₅H₁₂N₄O
SMILES

O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Edling AE, et al. An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. J Autoimmun. 2002 Mar;18(2):169-79. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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