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Cat. No.: HY-15591

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TMC647055

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC₅₀ value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1204416-97-6
Formule: C₃₂H₃₈N₄O₆S
Masse moléculaire:606.73

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

TMC647055 Chemical Structure

CAS No.: 1204416-97-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

EC90: 0.3 μM (Huh7-Luc cell)^[1].
EC50: 82 nM (HCV)^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>50 μM Compound: 10a, TMC647055	Cytotoxicity against HEK293T cells after 3 days by resazurin-based fluorescence analysis Cytotoxicity against HEK293T cells after 3 days by resazurin-based fluorescence analysis	[PMID: 24144360]
HepG2	CC₅₀	>50 μM Compound: 10a, TMC647055	Cytotoxicity against human HepG2 cells after 3 days by resazurin-based fluorescence analysis Cytotoxicity against human HepG2 cells after 3 days by resazurin-based fluorescence analysis	[PMID: 24144360]
Huh-7	CC₅₀	42.1 μM Compound: 10a, TMC647055	Cytotoxicity against human HuH7 cells Cytotoxicity against human HuH7 cells	[PMID: 24144360]
Huh-7	EC₅₀	>28 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 2b infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 2b infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	0.027 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	0.048 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	0.051 μM Compound: 10a, TMC647055	Antiviral activity against wild-type Hepatitis C virus Con 1b infected in human HuH7 by transient replicon assay Antiviral activity against wild-type Hepatitis C virus Con 1b infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	0.088 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 3a infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 3a infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	0.097 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 4a infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 4a infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	0.113 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 6a infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 6a infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	12.53 μM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 2a infected in human HuH7 by transient replicon assay Antiviral activity against Hepatitis C virus genotype 2a infected in human HuH7 by transient replicon assay	[PMID: 24144360]
Huh-7	EC₅₀	166 nM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7-SG cells after 3 days by RT-PCR analysis Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7-SG cells after 3 days by RT-PCR analysis	[PMID: 24144360]
Huh-7	EC₅₀	77 nM Compound: 10a, TMC647055	Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay	[PMID: 24144360]
Huh-7	EC₅₀	82 nM Compound: 18a, TMC647055	Antiviral activity against Hepatitic C virus genotype 1b clone ET infected in human Huh7 replicon cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitic C virus genotype 1b clone ET infected in human Huh7 replicon cells after 72 hrs by luciferase reporter gene assay	[PMID: 22633687]
MRC5	CC₅₀	>50 μM Compound: 10a, TMC647055	Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence analysis Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence analysis	[PMID: 24144360]
MT4	CC₅₀	28.9 μM Compound: 10a, TMC647055	Cytotoxicity against human MT4 cells Cytotoxicity against human MT4 cells	[PMID: 24144360]
Vero	CC₅₀	>50 μM Compound: 10a, TMC647055	Cytotoxicity against African green monkey Vero E6 cells after 3 days by resazurin-based fluorescence analysis Cytotoxicity against African green monkey Vero E6 cells after 3 days by resazurin-based fluorescence analysis	[PMID: 24144360]

In Vitro

TMC647055 has antiviral activity with an EC₉₀ value of 0.3 μM in Huh7-Luc cells^[1].
TMC647055 has potent combine activity with an EC₅₀ value of 82 nM in cellular HCV assays^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TMC647055 (compound 18a) (2 mg/kg, iv.; 10mg/kg, po.) shows an acceptable PK profile, characterized by high oral bioavailability and high systemic exposure after single oral dosing of 10 mg/kg, combined with a moderate plasma clearanceand low volume of distribution^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats^[2]
Dosage:

2 mg/kg; 10mg/kg
Administration:

2 mg/kg, iv.; 10mg/kg, po.; singel
Result:

No. Cl (L/h/kg) C_max(ng/mL) [Liver] (ng/mL) L/P F (%)

TMC647055 (compound 18a) 3.2 440 7800 46 ＞66

Chemical Information

CAS No. 1204416-97-6
Masse moléculaire 606.73
Formule C₃₂H₃₈N₄O₆S
SMILES

COC1=CC2=C(C=C1)C3=C(C4CCCCC4)C5=CC=C(C6=O)C=C5N3CC(C(N(C)CCOCCN(S(N6)(=O)=O)C)=O)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Journal Impact Factor

Plant Cell

SlSEC1- and SlSPY-mediated O-glycosylation stabilizes the transcription factor SlNOR to promote tomato fruit ripening. [Abstract]

2026 May 14:koag144. PMID: 42135064
Antiviral Res

Effects of RNA polymerase inhibitors on nucleotidylylation of human norovirus VPg. [Abstract]

2026 Jun 22:252:106470. PMID: 42331291
Antiviral Res

Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. [Abstract]

2019 Oct;170:104570. PMID: 31362004
Arch Microbiol

Antibacterial and antibiofilm efficacy of TMC647055 against methicillin-resistant Staphylococcus aureus. [Abstract]

2025 Nov 1;207(12):335. PMID: 41175257

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Devogelaere B, et al. TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage. Antimicrob Agents Chemother. 2012 Sep;56(9):4676-4684. [Content Brief]

[2]. Sandrine Vendeville, et al. Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4437-43. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

TMC647055

4 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Pureté et documentation
Références

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No.	Cl (L/h/kg)	C_max(ng/mL)	[Liver] (ng/mL)	L/P	F (%)
TMC647055 (compound 18a)	3.2	440	7800	46	＞66

TMC647055

Publications Citing Use of MedChemExpress (MCE) TMC647055

Activité biologique

Chemical Information

Publications (4)

Pureté et documentation

Références

Calculators

Help & FAQs

TMC647055 Related Classifications

HY-15591 Related Classifications