TPI-287
Based on 1 Customer Validation
TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.79%
- CAS No.: 849213-15-6
- Formule: C46H63NO15
- Masse moléculaire:869.99
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 849213-15-6
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Appearance Solid
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Masse moléculaire 869.99
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Formule C46H63NO15
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Color White to off-white
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SMILES
CC1(C)[C@@]2(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)CC(C)C)=O)C(C)=C1[C@]([H])(OC(C)=O)[C@@]3([H])[C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@]4([H])OC(C=C)O3)([H])[C@@H]2OC(C6=CC=CC=C6)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (114.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Pureté et documentation
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Fiche technique (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1494 mL | 5.7472 mL | 11.4944 mL | 28.7360 mL |
| 5 mM | 0.2299 mL | 1.1494 mL | 2.2989 mL | 5.7472 mL | |
| 10 mM | 0.1149 mL | 0.5747 mL | 1.1494 mL | 2.8736 mL | |
| 15 mM | 0.0766 mL | 0.3831 mL | 0.7663 mL | 1.9157 mL | |
| 20 mM | 0.0575 mL | 0.2874 mL | 0.5747 mL | 1.4368 mL | |
| 25 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1494 mL | |
| 30 mM | 0.0383 mL | 0.1916 mL | 0.3831 mL | 0.9579 mL | |
| 40 mM | 0.0287 mL | 0.1437 mL | 0.2874 mL | 0.7184 mL | |
| 50 mM | 0.0230 mL | 0.1149 mL | 0.2299 mL | 0.5747 mL | |
| 60 mM | 0.0192 mL | 0.0958 mL | 0.1916 mL | 0.4789 mL | |
| 80 mM | 0.0144 mL | 0.0718 mL | 0.1437 mL | 0.3592 mL | |
| 100 mM | 0.0115 mL | 0.0575 mL | 0.1149 mL | 0.2874 mL |
TPI-287 Related Classifications
HY-126899 Related Classifications
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