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Cat. No.: HY-P2074

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U 77436

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 128657-36-3
Formule: C₅₀H₇₆N₁₀O₁₁
Masse moléculaire:993.20

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 77436 Chemical Structure

CAS No.: 128657-36-3

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Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension^[1].

In Vivo

U 77436 (25 μg/rat; intratracheal administration) achieves an absorption rate of 52.1% in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 400-550 g)^[1]
Dosage:

25 μg/rat (intrapulmonary); 75 μg/rat (intravenous)
Administration:

intrapulmonary; single dose; intravenous; single dose
Result:

Achieved total recovery of 104.9% in bile and urine after intravenous administration, with 93.3% recovered in bile and 11.6% recovered in urine.
Achieved total recovery of 53.7% in bile and urine after intrapulmonary administration, with 48.0% recovered in bile and 5.7% recovered in urine.
Reached 52.1% intrapulmonary absorption relative to intravenous recovery.
Showed 63% of ⁵¹Cr-labeled dose reached the lungs, with an estimated 81% of the lung-delivered dose absorbed by 10 hours.

Chemical Information

CAS No. 128657-36-3
Masse moléculaire 993.20
Formule C₅₀H₇₆N₁₀O₁₁
SMILES

[O-][N+]1=CC=CC=C1CNC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC2=CN=CN2)N(C)C([C@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C(NC(CO)(CO)CO)=O)=O)=O)=O)=O)=O
Sequence

{Pro(NHCO-NH-C(CH2OH)3)}-Phe-{His(NCH3)}-Leu{(CHOH-CH2)}-Val-{Ile(NHCH2-C5H4NO)}
Sequence Shortening

{Pro(NHCO‑NH‑C(CH2OH)3)}‑F‑{His(NCH3)}-Leu{(CHOH‑CH2)}-V-{Ile(NHCH2-C5H4NO)}
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sheehy AM, et al. Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport. Pharm Res. 1993 Oct;10(10):1548-51. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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