ULK1/2-IN-1
ULK1/2-IN-1 is a tissue-targeted ULK1/2 inhibitor conjugated to the RGR (CRGRRST) tumor neovasculature-homing peptide. ULK1/2-IN-1 mediates autophagy inhibition and induces cytotoxicity in endothelial cells. ULK1/2-IN-1 can be used for the research of tumor-targeted autophagy inhibitors.
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- Formule: C55H86F3N21O15S
- Masse moléculaire:1370.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
ULK1 |
ULK2 |
In Vitro
ULK1/2-IN-1 (Compound 44) (2.5 μM; 18 h) shows cytotoxicity in HUVECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human umbilical vein endothelial cells (HUVECs)
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Concentration:2.5 μM
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Incubation Time:4 h, 18 h
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Result:Exhibited cytotoxicity in HUVECs at the 18 h, with variable results across replicates.
Chemical Information
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Masse moléculaire 1370.46
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Formule C55H86F3N21O15S
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SMILES
C[C@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(COCCOCCOCC(N1CC2=C(CC1)C=C(C=C2)NC3=NC=C(C(NC4CC4)=N3)C(F)(F)F)=O)=O)CS)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)C(O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ULK1/2-IN-1 Related Classifications
HY-181742 Related Classifications
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