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Cat. No.: HY-W141446

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VT00065

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VT00065 is a covalent DHS inhibitor. VT00065 forms a redox-dependent covalent bond with the catalytic lysine K329 of DHS, locking the enzyme in an inactive state.

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CAS No.: 144163-68-8
Formule: C₅H₈N₂S
Masse moléculaire:128.20

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

VT00065 Chemical Structure

CAS No.: 144163-68-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

VT00065 is a covalent DHS inhibitor. VT00065 forms a redox-dependent covalent bond with the catalytic lysine K329 of DHS, locking the enzyme in an inactive state^[1].

In Vitro

VT00065 (100 mM; 24 h) covalently and specifically modifies the catalytic K329 residue of purified human DHS, suggesting it acts as a mechanism-based binder with potential to irreversibly inactivate the enzyme, though it exhibits low binding occupancy^[1].
VT00065 (2-20 mM; 9 min) exhibits weak, dose-dependent inhibition of deoxyhypusination activity in purified human DHS-eIF5A reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 144163-68-8
Appearance Liquid (Density: 1.126±0.06 g/cm³)
Masse moléculaire 128.20
Formule C₅H₈N₂S
Color Colorless to light yellow
SMILES

CNCC1=NC=CS1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wilk P, et al. Crystallographic fragment screening supports tool compound discovery and reveals conformational flexibility in human deoxyhypusine synthase. Commun Chem. 2026;9(1):66. Published 2026 Jan 17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
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VT00065

Cell Cycle/DNA Damage Compound Library

Anti-Aging Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Amine Fragment Library

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VT00065

Cell Cycle/DNA Damage Compound Library

Anti-Aging Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Amine Fragment Library

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VT00065 Related Classifications

HY-W141446 Related Classifications