ZD6021
ZD6021 is an orally active Neurokinin 1 Receptor antagonist, with Ki values of 0.12 nM for NK1 and 0.62 nM for NK2. At a concentration of 100 nM, ZD6021 has a pKB value of 8.9 for human pulmonary artery NK1 receptors, and a pKB value of 7.3 for human bronchial NK2 receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED50 of 0.5 mg/kg, and also decreases NK2 mediated bronchoconstriction, with an ED50 of 13 mg/kg.
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- CAS No.: 255049-08-2
- Formule: C35H35Cl2N3O2S
- Masse moléculaire:632.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 255049-08-2
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Masse moléculaire 632.64
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Formule C35H35Cl2N3O2S
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SMILES
O=C(N(C)C[C@@H](CCN1CCC(CC1)C2=CC=CC=C2[S@](C)=O)C3=CC=C(C(Cl)=C3)Cl)C4=C5C=CC=CC5=CC(C#N)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZD6021 Related Classifications
HY-118378 Related Classifications
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