CHIKV-IN-6 

CHIKV-IN-6 is a selective CHIKV inhibitor with no cytotoxicity to mammalian cells. CHIKV-IN-6 inhibits CHIKV replication and exhibits little to no activity against other Togaviridae family members. CHIKV-IN-6 can be used for the research of chikungunya virus infection^[1].

CHIKV-IN-6 (compound 15b) (7 days post-infection) potently inhibits CHIKV (strain 899) replication in Vero cells with an EC₅₀ of 3 μM and shows no cytotoxicity up to 668 μM^[1].
CHIKV-IN-6 (2 days post-infection) potently inhibits replication of multiple CHIKV laboratory strains and clinical isolates in Vero E6 cells, with EC₅₀ values ranging from 0.75 μM to 2.9 μM, and shows no cytotoxicity up to 300 μM^[1].
CHIKV-IN-6 (7 days post-infection) shows only marginal antiviral activity against Sindbis virus (HRsp strain) and Semliki Forest virus in Vero cells, with EC₅₀ values of 69 μM and 219 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

299.33

C₁₅H₁₇N₅O₂

1609009-17-7

O=C1C(N=NN2C3=CC=CC(OC(C)C)=C3)=C2N=C(CC)N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gigante A, et al. Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication. J Med Chem. 2014 May 22;57(10):4000-8.  [Content Brief]