Cat. No.: HY-130237

Cinnamtannin B-1

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Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active.

For research use only. We do not sell to patients.

Purity: 99.16%
CAS No.: 88082-60-4
Formula: C₄₅H₃₆O₁₈
Molecular Weight:864.76

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Cinnamtannin B-1 Chemical Structure

CAS No.: 88082-60-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	>10 μg/mL Compound: 54	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HCT-8	ED₅₀	>10 μg/mL Compound: 54	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
KB	ED₅₀	>10 μg/mL Compound: 54	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
TE-671	ED₅₀	>10 μg/mL Compound: 54	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]

In Vitro

Cinnamtannin B-1 (0-100 μM, 1-5 days) downregulates osteoclast differentiation-related gene expressions (such as Ctsk, Mmp9, Acp5, ATP6V0d2, and NFATc1), reduces the protein expression of NFATc1 and c-Fos, inhibits RANKL-induced osteoclast formation and bone resorption function in mouse bone marrow macrophages^[1].
Cinnamtannin B-1 (0-100 μM, 1-3 days) inhibits the viability of cancer cells DLD-1, COLO 201 and HCT-116 (IC₅₀s are 32 μM, 35 μM and 58.8 μM, respectively), arrests the cell cycle at G2/M phase, and induces apoptosis in DLD-1 and COLO 201^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

DLD-1, COLO 201 and HCT-116
Concentration:

0-100 μM
Incubation Time:

24-72 h
Result:

Inhibited the cell viability.

Western Blot Analysis^[1]

Cell Line:

mouse bone marrow macrophage
Concentration:

0-10 μM
Incubation Time:

4 h
Result:

Downregulated the expression of NFATc1 and c-Fos.

In Vivo

Cinnamtannin B-1 (20 mg/kg, ig, 5 times a week for 5 weeks) prevents ovariectomy (OVX)-induced osteoporosis in C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OVX-induced osteoporosis in C57BL/6 mice^[1]
Dosage:

20 mg/kg
Administration:

ig, 5 times a week for 5 weeks
Result:

Increased the bone density, increased the bone volume fraction (BV/TV), the number of trabeculae (Tb.N) and the thickness of trabeculae (Tb.Th), decreased the trabecular separation (Tb.Sp).

Chemical Information

CAS No. 88082-60-4
Appearance Solid
Molecular Weight 864.76
Formula C₄₅H₃₆O₁₈
Color White to pink
SMILES

O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C4C(O[C@]5(C6=CC=C(O)C(O)=C6)OC7=CC(O)=CC(O)=C7[C@@]4([H])[C@H]5O)=CC(O)=C3[C@@H]1C8=C9C(C[C@@H](O)[C@@H](C%10=CC=C(O)C(O)=C%10)O9)=C(O)C=C8O
Structure Classification
- Flavonoids
- Anthocyans
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (115.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1564 mL

5.7820 mL

11.5639 mL

5 mM

0.2313 mL

1.1564 mL

2.3128 mL

10 mM

0.1156 mL

0.5782 mL

1.1564 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Meng Li, et al. Cinnamtannin B-1 Prevents Ovariectomy-Induced Osteoporosis via Attenuating Osteoclastogenesis and ROS Generation. Front Pharmacol. 2020 Jul 10;11:1023. [Content Brief]

[2]. Patrick P Carriere, et al. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer.Int J Oncol. 2018 Oct;53(4):1442-1454. [Content Brief]

[3]. Fujita K, et al., Cinnamtannin B-1 Promotes Migration of Mesenchymal Stem Cells and Accelerates Wound Healing in Mice. PLoS One. 2015 Dec 11;10(12):e0144166. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1564 mL	5.7820 mL	11.5639 mL	28.9098 mL
	5 mM	0.2313 mL	1.1564 mL	2.3128 mL	5.7820 mL
	10 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	15 mM	0.0771 mL	0.3855 mL	0.7709 mL	1.9273 mL
	20 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	25 mM	0.0463 mL	0.2313 mL	0.4626 mL	1.1564 mL
	30 mM	0.0385 mL	0.1927 mL	0.3855 mL	0.9637 mL
	40 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7227 mL
	50 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.5782 mL
	60 mM	0.0193 mL	0.0964 mL	0.1927 mL	0.4818 mL
	80 mM	0.0145 mL	0.0723 mL	0.1445 mL	0.3614 mL
	100 mM	0.0116 mL	0.0578 mL	0.1156 mL	0.2891 mL

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Cinnamtannin B-1

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Phenols Library

Pyroptosis Compound Library

Orally Active Compound Library

Flavonoids Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Food-Sourced Compound Library

Anti-Liver Cancer Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Coagulation and Anti-coagulation Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Radioprotector Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

All NF-κB Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cinnamtannin B-1 Related Classifications

HY-130237 Related Classifications