1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. CM03

CM03 

Cat. No.: HY-121862
Handling Instructions

CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells.

For research use only. We do not sell to patients.

CM03 Chemical Structure

CM03 Chemical Structure

CAS No. : 2101208-44-8

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Description

CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells[1][2].

IC50 & Target

DNA synthesis[1]

In Vitro

CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA (HY-10221) in MIA PaCa-2 and PANC-1[1].
CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 and PANC-1
Concentration: 0.4 μM
Incubation Time: 24 h for MIA PaCa-2, 48 h for PANC-1
Result: Significantly increased the level of γ-H2AX protein when in combination with SAHA (HY-10221) (1 μM).

Cell Proliferation Assay[2]

Cell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3
Concentration: 0-100 nM
Incubation Time: 96 h
Result: Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI50s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.
Molecular Weight

632.75

Formula

C34H44N6O6

CAS No.
SMILES

O=C(C1=CC=C2C3=O)N(C(C4=C1C2=C(C=C4NCCN5CCCC5)C(N3CCCN6CCOCC6)=O)=O)CCCN7CCOCC7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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