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Cat. No.: HY-182291

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COX-1/2-IN-11

COX-1/2-IN-11 is a dual inhibitor of COX-1 and COX-2, with an IC₅₀ of 345 nM against COX-1. COX-1/2-IN-11 can be used in the development of non-steroidal anti-inflammatory agents.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₅ClF₃N₃O
Molecular Weight:405.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-1/2-IN-11 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

COX-1/2-IN-11 is a dual inhibitor of COX-1 and COX-2, with an IC₅₀ of 345 nM against COX-1. COX-1/2-IN-11 can be used in the development of non-steroidal anti-inflammatory agents^[1].

IC₅₀ & Target^[1]

COX-1

345 nM ()

COX-2

All COX Isoforms :

In Vitro

COX-1/2-IN-11 (10 μM) (Compound 9) exhibits high inhibitory activity against COX-1 and COX-2 at a concentration of 10 μM, with inhibition rates of 94% and 96%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 405.80
Formula C₂₀H₁₅ClF₃N₃O
SMILES

ClC(C=C1)=CC=C1N2N=C(C(F)(F)F)C=C2C3=CC=C4C(CCC(N4C)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tashima T, et al. Synthesis and biological evaluation of structurally L-shaped carbostyril derivatives with integrated side chains as cyclooxygenase inhibitors. Bioorg Med Chem Lett. Published online March 19, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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COX-1/2-IN-11

All COX Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

COX-1/2-IN-11 Related Classifications

HY-182291 Related Classifications