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Cat. No.: HY-118625

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CP-457920

CP-457920 (Compound 21) is a GABA receptor inhibitor (K_i ≈ 1 ng/mL). CP-457920 can be used in research on neurological diseases such as Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 220860-50-4
Formula: C₁₈H₁₇N₃O₃
Molecular Weight:323.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CP-457920 Chemical Structure

CAS No.: 220860-50-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CP-457920 (Compound 21) is a GABA receptor inhibitor (K_i ≈ 1 ng/mL). CP-457920 can be used in research on neurological diseases such as Alzheimer's disease^[1].

Chemical Information

CAS No. 220860-50-4
Molecular Weight 323.35
Formula C₁₈H₁₇N₃O₃
SMILES

O=C(C1=CNC2=CC=C(OCC)N=C2C1=O)NCC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pamela A. Albaugh, et al. Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands. US6143760. 2018-08-25.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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